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Application of precision instruments in medical industry

Date:2017/7/21 15:16:23 Hits:1238
    Molecular pathology has applications. I refer to the relevant literature summarizes application of electron microscopy in the diagnosis of tumor, virus and viral diseases, systemic diseases and other research fields, which is one of the most important tools of modern clinical research and diagnosis of diseases.

    Application characteristics of electron microscopy in medical field
    With the development of science and technology, electron microscope magnification from ten times the first electron microscope to millions of times now, so in the field of biomedical ultrastructure by electron microscopy observation of the high performance organelles of normal and pathological cells, such as endoplasmic reticulum, mitochondria, Golgi apparatus and lysosomes, cytoskeleton system etc., are of great help to explore the etiology and treatment of disease. Through studying the relation between the structure and function of cells, can also study the communication and transportation, cell division and differentiation, proliferation and regulation of the laws of life activities, electron microscopy ultrastructure can be combined with various sample preparation technique to observe the virus, bacteria, mycoplasma and other biological molecules, is no substitute for modern biomedical research tools.

    Application of electron microscopy in tumor diagnosis
    Application of electron microscopy is based on optical microscopy, optical microscope resolution is 0.2Lm, transmission electron microscope, resolution of 0.2nm, that is to say the transmission electron microscope magnified 1000 times based on optical microscopy. Therefore, transmission electron microscopy breaks through the limitation of low resolution of optical microscopy and becomes a new tool for the diagnosis of difficult tumors. Studies have reported that non pigmented tumors, eosinophils, myogenic tumors, soft tissue, alveolar sarcomas, and neuroendocrine tumors can be clearly diagnosed by light microscopy, which can be clearly diagnosed by electron microscopy.
    The electron microscope mainly aims to identify the differentiation markers of the tissue cells by meticulous observation of the ultrastructure, and to identify and identify the corresponding tumor types. Apoptosis is closely related to tumor, was studied on cell apoptosis plays an important role, so the ultrastructural pathological changes and cell apoptosis cells were observed by electron microscope, which will provide scientific basis for the diagnosis and treatment of tumor.

    Application of electron microscopy in differential diagnosis of tumor
    Transmission electron microscopy the tissue cells, biological macromolecules, viruses, bacteria and other pathological structure, structure of different disease observed, can also identify some tumor diseases, studies have reported by electron microscopy ultrastructural observation can distinguish cancer, melanoma and sarcoma and carcinoma and mesothelioma; distinguishing of thymoma thymus carcinoid, malignant lymphoma and germ cell tumors; distinguishing neuroblastoma, embryonal rhabdomyoma, Ewing's sarcoma, malignant lymphoma and small cell carcinoma; distinguishing fibrosarcoma, malignant fibrous histiocytoma, leiomyosarcoma and malignant schwannoma and spindle cell carcinoma and sarcoma (Yang Guanghua, 1992).
    Renal biopsy is very important for understanding the occurrence, development and selection of treatment, and can improve the accuracy of the diagnosis. The present methods with immunohistochemistry and electron microscopy, electron microscopy can make up for the defect of optical microscope resolution is not high, can be observed the ultrastructural pathological changes that are invisible to components, especially in epithelial cells, mesangial cells, muscle membrane and interstitial changes, determine whether the electronic dense and calm. Siegel reported that through the analysis of 213 cases of renal biopsy data, found that 11% cases diagnosed by electron microscopy, the ultrastructure of 36% cases of renal changes confirmed or sub classification of light microscope diagnosis, such as hereditary nephritis, glomerular disease histological features no special change, only to electron microscopy to make an accurate diagnosis.
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